doc. Ing. Michal Pásek, Ph.D.

Education

2010: Assoc. Prof. – Faculty of Mechanical Engineering, Brno University of Technology “Computational modelling in the research of electrophysiological processes in cardiac cells“.

2000: PhD. – Faculty of Mechanical Engineering, Brno University of Technology  ”Computational modelling of physiological processes in cardiac cells: block of membrane channels“.

1995: MSc. – Faculty of Mechanical Engineering, Brno University of Technology.

Employments

since 2000: Teacher at the Department of Physiology of Medical Faculty of Masaryk University Brno (practicals, demonstrations, lectures).

since 1999: Research worker at the Institute of Thermomechanics of  the Academy of Science of the Czech Republic. Specialisation: computational modelling of electrophysiological processes in cardiac cells (excitation-contraction coupling, arrhytmogenesis, drug-channel interactions and others).

Research stays

2005–2011: Five stays in the Laboratory of Cellular and Molecular Cardiology at the University of Bristol (Prof. C. H. Orchard).

2003: One stay in the Laboratory of Fundamental and Applied Bioenergetics at the University of Joseph Fourier in Grenoble (Prof. V. Sack).

Membership in scientific societies

since 2012: Member of the European Working Group on Cardiac Cellular Electrophysiology.

2005–2017: Member of the Physiological Society (UK).

Membership in editorial boards of international journals

since 2012: Field editor of the international journal General Physiology and Biophysics.

2020: Guest editor of special issue of the international journal Progress in Biophysics and Molecular Biology.

Awards

1999: Award of Prof. Valenta and Prof. Čihák for Biomechanics.

2005: Award of the Institute of Thermomechanics of the CAS for the best paper published in 2004.

2007: Award of the Institute of Thermomechanics of the CAS for the best paper published in 2006.

Principal investigator of projects

Functional role of t-tubules in the models of ventricular cardiomyocytes (Junior Fellowship, The Physiological Society, 2005–2007).

Quantitative analysis of effects of t-tubules on electrical activity of cardiomyocytes (GAČR 204/02/D129, 2002–2004).

Participation in projects

MZ: NV16-30571A (2016–2020), NT14301 (2013–2015)

AV0Z: 20760514 (2005–2011), 2076919 (1999–2004)

MŠMT: MSM0021622402 (2005–2011), J07/98:141100004 (2000–2004)

GAČR: 305/04/1385 (2004–2006), 305/97/0043 (1997–1999), 106/96/0652 (1996–1998)

Publications and citations

Author of more than 90 scientific publications (in extenso) including 33 impacted papers. 404 citations according to Web of Science (without self-citations),
h-index = 13.

Selected publications

Pásek M., Bébarová M., Šimurdová M., Šimurda J.: Functional consequences of changes in the distribution of Ca²⁺ extrusion pathways between t-tubular and surface membranes in a model of human ventricular cardiomyocyte. J. Mol. Cell. Cardiol., 2024, Vol. 193, p. 113-124 (IF = 4.9).

Pásek M., Šimurda J., Bébarová M., Christé G.: Divergent estimates of the ratio between Na⁺-Ca²⁺ current densities in t-tubular and surface membranes of rat ventricular cardiomyocytes. J. Cell. Sci., 2021, Vol. 134, jcs258228 (IF = 5.235).

Pásek M., Šimurda J., Orchard C. H., Christé G.: A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse–axial tubular system. Progress Biophys Mol Biol, 2008, Vol. 96, p. 258-280 (IF = 6.388).

Pásek M., Brette F., Nelson A., Pearce C., Qaiser A., Christé G., Orchard C. H.: Quantification of t-tubule area and protein distribution in rat cardiac ventricular myocytes. Progress Biophys Mol Biol, 2008, Vol. 96, p. 244-257 (IF = 6.388).

Pásek M., Šimurda J., Christé G., Orchard C.H.: Modelling the cardiac transverse-axial tubular system (review). Progress Biophys Mol Biol, 2008, Vol. 96, p. 226-243 (IF = 6.388).

Grants